APIP (APAF1 interacting protein)

2012-08-01  

Identity

HGNC
APIP
LOCATION
11p13
LOCUSID
51074
ALIAS
APIP2,CGI-29,CGI29,MMRP19,hAPIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51074
MIM: 612491
HGNC: 17581
Ensembl: ENSG00000149089

Variants:

dbSNP: 51074
ClinVar: 51074
TCGA: ENSG00000149089
COSMIC: APIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149089ENST00000395787Q96GX9
ENSG00000149089ENST00000532428S4R3D6

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Methionine salvage pathwayREACTOMER-HSA-1237112
Sulfur amino acid metabolismREACTOMER-HSA-1614635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
228373972012Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.29
152629852004Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.22
232852112012Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway.15
243670892014Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.14
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
224074862012Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.10
269428722016APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.4
231920372012Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein.1

Citation

Dessen P

APIP (APAF1 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52845/apip-(apaf1-interacting-protein)