APIP (APAF1 interacting protein)

2012-08-01  

Identity

HGNC
APIP
LOCATION
11p13
LOCUSID
51074
ALIAS
APIP2,CGI-29,CGI29,MMRP19,hAPIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51074
MIM: 612491
HGNC: 17581
Ensembl: ENSG00000149089

Variants:

dbSNP: 51074
ClinVar: 51074
TCGA: ENSG00000149089
COSMIC: APIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149089ENST00000395787Q96GX9
ENSG00000149089ENST00000532428S4R3D6

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Methionine salvage pathwayREACTOMER-HSA-1237112
Sulfur amino acid metabolismREACTOMER-HSA-1614635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384232482024APIP regulated by YAP propels methionine cycle and metastasis in head and neck squamous cell carcinoma.0
384232482024APIP regulated by YAP propels methionine cycle and metastasis in head and neck squamous cell carcinoma.0
312631052019Cardioprotective role of APIP in myocardial infarction through ADORA2B.5
312631052019Cardioprotective role of APIP in myocardial infarction through ADORA2B.5
269428722016APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.6
269428722016APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.6
243670892014Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.20
243670892014Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.20
224074862012Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.15
228373972012Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.39
231920372012Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein.1
232852112012Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway.19
224074862012Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.15
228373972012Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.39
231920372012Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein.1

Citation

Dessen P

APIP (APAF1 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52845/apip-(apaf1-interacting-protein)