APIP (APAF1 interacting protein)

2012-08-01  

Identity

HGNC
LOCATION
11p13
LOCUSID
ALIAS
APIP2,CGI-29,CGI29,MMRP19,hAPIP
FUSION GENES

Other Information

Locus ID:

NCBI: 51074
MIM: 612491
HGNC: 17581
Ensembl: ENSG00000149089

Variants:

dbSNP: 51074
ClinVar: 51074
TCGA: ENSG00000149089
COSMIC: APIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149089ENST00000395787Q96GX9
ENSG00000149089ENST00000532428S4R3D6

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Methionine salvage pathwayREACTOMER-HSA-1237112
Sulfur amino acid metabolismREACTOMER-HSA-1614635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384232482024APIP regulated by YAP propels methionine cycle and metastasis in head and neck squamous cell carcinoma.0
384232482024APIP regulated by YAP propels methionine cycle and metastasis in head and neck squamous cell carcinoma.0
312631052019Cardioprotective role of APIP in myocardial infarction through ADORA2B.5
312631052019Cardioprotective role of APIP in myocardial infarction through ADORA2B.5
269428722016APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.6
269428722016APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.6
243670892014Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.20
243670892014Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.20
224074862012Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.15
228373972012Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.39
231920372012Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein.1
232852112012Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway.19
224074862012Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.15
228373972012Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.39
231920372012Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein.1

Citation

Dessen P

APIP (APAF1 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52845/gene-fusions-explorer/meetings/humanGenome