TREM1 (triggering receptor expressed on myeloid cells 1)

2012-09-01  

Identity

HGNC
TREM1
LOCATION
6p21.1
LOCUSID
54210
ALIAS
CD354,TREM-1

Other Information

Locus ID:

NCBI: 54210
MIM: 605085
HGNC: 17760
Ensembl: ENSG00000124731

Variants:

dbSNP: 54210
ClinVar: 54210
TCGA: ENSG00000124731
COSMIC: TREM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124731ENST00000244709Q9NP99
ENSG00000124731ENST00000244709Q38L15
ENSG00000124731ENST00000334475Q9NP99
ENSG00000124731ENST00000589614K7EKM5
ENSG00000124731ENST00000591620Q9NP99

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381914202024Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies.1
382037982024The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells.0
383704182024Molecular and immunological features of TREM1 and its emergence as a prognostic indicator in glioma.0
384795522024Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.0
385771932024sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis.0
387493772024TREM1: Activation, signaling, cancer and therapy.0
381914202024Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies.1
382037982024The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells.0
383704182024Molecular and immunological features of TREM1 and its emergence as a prognostic indicator in glioma.0
384795522024Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.0
385771932024sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis.0
387493772024TREM1: Activation, signaling, cancer and therapy.0
361813382023TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.5
368114982023Dengue Virus Increases the Expression of TREM-1 and CD10 on Human Neutrophils.0
368153152023Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid-soluble TREM2.3

Citation

Dessen P

TREM1 (triggering receptor expressed on myeloid cells 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52855/trem1-(triggering-receptor-expressed-on-myeloid-cells-1)