CYSLTR2 (cysteinyl leukotriene receptor 2)

2012-09-01  

Identity

HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
CYSLT2,CYSLT2R,GPCR21,HG57,HPN321,KPG_011,PSEC0146,hGPCR21
FUSION GENES

Other Information

Locus ID:

NCBI: 57105
MIM: 605666
HGNC: 18274
Ensembl: ENSG00000152207

Variants:

dbSNP: 57105
ClinVar: 57105
TCGA: ENSG00000152207
COSMIC: CYSLTR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152207ENST00000282018Q9NS75
ENSG00000152207ENST00000282018Q5KU17
ENSG00000152207ENST00000614739Q9NS75
ENSG00000152207ENST00000614739Q5KU17
ENSG00000152207ENST00000617562A0A1B0GXM0
ENSG00000152207ENST00000621321A0A1B0GXM0
ENSG00000152207ENST00000622559A0A1B0GXM0

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Leukotriene receptorsREACTOMER-HSA-391906
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
270891792016Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.57
136795722003Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.39
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
192649732009Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.36
159707962005Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics.29
174605472007Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.28
174605472007Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.28
166068352006Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.25
155455222004Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure.20

Citation

Dessen P

CYSLTR2 (cysteinyl leukotriene receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52856/cysltr2-(cysteinyl-leukotriene-receptor-2)