CYSLTR2 (cysteinyl leukotriene receptor 2)

2012-09-01 Affiliation

Identity

HGNC

CYSLTR2

LOCATION

13q14.2

LOCUSID

57105

ALIAS

CYSLT2,CYSLT2R,GPCR21,HG57,HPN321,KPG_011,PSEC0146,hGPCR21

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57105
MIM: 605666
HGNC: 18274
Ensembl: ENSG00000152207

Variants:

dbSNP: 57105
ClinVar: 57105
TCGA: ENSG00000152207
COSMIC: CYSLTR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152207	ENST00000282018	Q9NS75
ENSG00000152207	ENST00000282018	Q5KU17
ENSG00000152207	ENST00000614739	Q9NS75
ENSG00000152207	ENST00000614739	Q5KU17
ENSG00000152207	ENST00000617562	A0A1B0GXM0
ENSG00000152207	ENST00000621321	A0A1B0GXM0
ENSG00000152207	ENST00000622559	A0A1B0GXM0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Eicosanoid ligand-binding receptors	REACTOME	R-HSA-391903
Leukotriene receptors	REACTOME	R-HSA-391906
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
27089179	2016	Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.	57
13679572	2003	Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.	39
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
19264973	2009	Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.	36
15970796	2005	Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics.	29
17460547	2007	Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.	28
17460547	2007	Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.	28
16606835	2006	Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.	25
15545522	2004	Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure.	20

Citation

Dessen P

CYSLTR2 (cysteinyl leukotriene receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52856/cysltr2-(cysteinyl-leukotriene-receptor-2)