CYSLTR2 (cysteinyl leukotriene receptor 2)

2012-09-01  

Identity

HGNC
CYSLTR2
LOCATION
13q14.2
LOCUSID
57105
ALIAS
CYSLT2,CYSLT2R,GPCR21,HG57,HPN321,KPG_011,PSEC0146,hGPCR21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57105
MIM: 605666
HGNC: 18274
Ensembl: ENSG00000152207

Variants:

dbSNP: 57105
ClinVar: 57105
TCGA: ENSG00000152207
COSMIC: CYSLTR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152207ENST00000282018Q9NS75
ENSG00000152207ENST00000282018Q5KU17
ENSG00000152207ENST00000614739Q9NS75
ENSG00000152207ENST00000614739Q5KU17
ENSG00000152207ENST00000617562A0A1B0GXM0
ENSG00000152207ENST00000621321A0A1B0GXM0
ENSG00000152207ENST00000622559A0A1B0GXM0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Leukotriene receptorsREACTOMER-HSA-391906
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380885142024The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.0
380885142024The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.0
368348202023DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.1
368348202023DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.1
357778532022Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.1
357778532022Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.1
332886752021Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.17
335887872021Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.8
337534962021The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.36
332886752021Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.17
335887872021Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.8
337534962021The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.36
316143582020Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.6
316143582020Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.6
311265152019Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population.3

Citation

Dessen P

CYSLTR2 (cysteinyl leukotriene receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52856/cysltr2-(cysteinyl-leukotriene-receptor-2)