LARP7 (La ribonucleoprotein 7, transcriptional regulator)

2012-09-01  

Identity

HGNC
LARP7
LOCATION
4q25
LOCUSID
51574
ALIAS
ALAZS,HDCMA18P,PIP7S,hLARP7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51574
MIM: 612026
HGNC: 24912
Ensembl: ENSG00000174720

Variants:

dbSNP: 51574
ClinVar: 51574
TCGA: ENSG00000174720
COSMIC: LARP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174720ENST00000324052Q4G0J3
ENSG00000174720ENST00000344442Q4G0J3
ENSG00000174720ENST00000505034D6RFF0
ENSG00000174720ENST00000505216D6RBH8
ENSG00000174720ENST00000507443D6RAF3
ENSG00000174720ENST00000508577D6RF49
ENSG00000174720ENST00000509061Q4G0J3
ENSG00000174720ENST00000509622D6RBH8
ENSG00000174720ENST00000511529H0YA82
ENSG00000174720ENST00000512589D6RF22
ENSG00000174720ENST00000513553D6R9Z6
ENSG00000174720ENST00000651579Q4G0J3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
204102712010Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction.122
182491482008A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.121
182816982008LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.112
184834872008The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.74
228658332012Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.27
233402092013Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.22
2195749520117SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.21
257536632015Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.20
250537412014LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.18
224881522012LARP7 is a potential tumor suppressor gene in gastric cancer.17

Citation

Dessen P

LARP7 (La ribonucleoprotein 7, transcriptional regulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52870/larp7-(la-ribonucleoprotein-7-transcriptional-regulator)