LARP7 (La ribonucleoprotein 7, transcriptional regulator)

2012-09-01  

Identity

HGNC
LARP7
LOCATION
4q25
LOCUSID
51574
ALIAS
ALAZS,HDCMA18P,PIP7S,hLARP7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51574
MIM: 612026
HGNC: 24912
Ensembl: ENSG00000174720

Variants:

dbSNP: 51574
ClinVar: 51574
TCGA: ENSG00000174720
COSMIC: LARP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174720ENST00000324052Q4G0J3
ENSG00000174720ENST00000344442Q4G0J3
ENSG00000174720ENST00000505034D6RFF0
ENSG00000174720ENST00000505216D6RBH8
ENSG00000174720ENST00000507443D6RAF3
ENSG00000174720ENST00000508577D6RF49
ENSG00000174720ENST00000509061Q4G0J3
ENSG00000174720ENST00000509622D6RBH8
ENSG00000174720ENST00000511529H0YA82
ENSG00000174720ENST00000512589D6RF22
ENSG00000174720ENST00000513553D6R9Z6
ENSG00000174720ENST00000651579Q4G0J3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
331314232021Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.9
335698792021Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.2
336632212021LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.24
341078502021Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.13
348185432021LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.21
331314232021Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.9
335698792021Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.2
336632212021LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.24
341078502021Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.13
348185432021LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.21
320178982020The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness.22
327266372020L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.0
328883912020Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome.2
333563422020Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism.2
320178982020The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness.22

Citation

Dessen P

LARP7 (La ribonucleoprotein 7, transcriptional regulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52870/larp7-(la-ribonucleoprotein-7-transcriptional-regulator)