IRX4 (iroquois homeobox 4)

2012-09-01  

Identity

HGNC
IRX4
LOCATION
5p15.33
LOCUSID
50805
ALIAS
IRXA3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 50805
MIM: 606199
HGNC: 6129
Ensembl: ENSG00000113430

Variants:

dbSNP: 50805
ClinVar: 50805
TCGA: ENSG00000113430
COSMIC: IRX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113430ENST00000231357P78413
ENSG00000113430ENST00000505790P78413
ENSG00000113430ENST00000508261D6RC00
ENSG00000113430ENST00000511126D6RAS8
ENSG00000113430ENST00000513692P78413
ENSG00000113430ENST00000613726P78413
ENSG00000113430ENST00000622814P78413

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
378611982024Dynamics and recognition of homeodomain containing protein-DNA complex of IRX4.0
378611982024Dynamics and recognition of homeodomain containing protein-DNA complex of IRX4.0
339192002021Identification and Characterization of Alternatively Spliced Transcript Isoforms of IRX4 in Prostate Cancer.4
339192002021Identification and Characterization of Alternatively Spliced Transcript Isoforms of IRX4 in Prostate Cancer.4
328948172020Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer.4
328948172020Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer.4
240223002014Variants at IRX4 as prostate cancer expression quantitative trait loci.22
240223002014Variants at IRX4 as prostate cancer expression quantitative trait loci.22
223233582012IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.28
223233582012IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.28
215445822011Two novel mutations of the IRX4 gene in patients with congenital heart disease.17
217793812011Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.6
215445822011Two novel mutations of the IRX4 gene in patients with congenital heart disease.17
217793812011Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.6
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15

Citation

Dessen P

IRX4 (iroquois homeobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52873/irx4-(iroquois-homeobox-4)