GFUS (GDP-L-fucose synthase)

2012-09-01 Affiliation

Identity

HGNC

GFUS

LOCATION

8q24.3

LOCUSID

7264

ALIAS

FX,P35B,SDR4E1,TSTA3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7264
MIM: 137020
HGNC: 12390
Ensembl: ENSG00000104522

Variants:

dbSNP: 7264
ClinVar: 7264
TCGA: ENSG00000104522
COSMIC: GFUS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104522	ENST00000425753	Q13630
ENSG00000104522	ENST00000425753	A0A140VKC8
ENSG00000104522	ENST00000524719	H0YCP7
ENSG00000104522	ENST00000526290	E9PLH9
ENSG00000104522	ENST00000527006	H0YE90
ENSG00000104522	ENST00000529048	E9PKL9
ENSG00000104522	ENST00000529064	Q13630
ENSG00000104522	ENST00000529064	A0A140VKC8
ENSG00000104522	ENST00000530474	E9PP60
ENSG00000104522	ENST00000533817	E9PP14

Pathways

Pathway	Source	External ID
Fructose and mannose metabolism	KEGG	ko00051
Amino sugar and nucleotide sugar metabolism	KEGG	ko00520
Fructose and mannose metabolism	KEGG	hsa00051
Amino sugar and nucleotide sugar metabolism	KEGG	hsa00520
Metabolic pathways	KEGG	hsa01100
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	REACTOME	R-HSA-446193
Synthesis of substrates in N-glycan biosythesis	REACTOME	R-HSA-446219
GDP-fucose biosynthesis	REACTOME	R-HSA-6787639

References

Pubmed ID	Year	Title	Citations
34979755	2022	[TSTA3 gene promotes esophageal cancer invasion through MAPK-ERK pathway and downstream MMP2/9].	0
36583336	2022	FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation.	2
34979755	2022	[TSTA3 gene promotes esophageal cancer invasion through MAPK-ERK pathway and downstream MMP2/9].	0
36583336	2022	FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation.	2
33042286	2020	TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2.	11
33042286	2020	TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2.	11
29950151	2018	High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC.	8
29950151	2018	High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC.	8
26531722	2016	Oncogenic potential of TSTA3 in breast cancer and its regulation by the tumor suppressors miR-125a-5p and miR-125b.	25
26531722	2016	Oncogenic potential of TSTA3 in breast cancer and its regulation by the tumor suppressors miR-125a-5p and miR-125b.	25
23774504	2013	The crystal structure of human GDP-L-fucose synthase.	4
23774504	2013	The crystal structure of human GDP-L-fucose synthase.	4
22528125	2012	Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation.	15
22528125	2012	Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation.	15

Citation

Dessen P

GFUS (GDP-L-fucose synthase)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52892/gfus-(gdp-l-fucose-synthase)

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