GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

2012-09-01 Affiliation

Identity

HGNC

GRIA2

LOCATION

4q32.1

LOCUSID

2891

ALIAS

GLUR2,GLURB,GluA2,GluR-K2,HBGR2,NEDLIB,gluR-2,gluR-B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2891
MIM: 138247
HGNC: 4572
Ensembl: ENSG00000120251

Variants:

dbSNP: 2891
ClinVar: 2891
TCGA: ENSG00000120251
COSMIC: GRIA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120251	ENST00000264426	P42262
ENSG00000120251	ENST00000296526	P42262
ENSG00000120251	ENST00000323661	F8W7L6
ENSG00000120251	ENST00000393815	P42262
ENSG00000120251	ENST00000503437	D6REK8
ENSG00000120251	ENST00000505888	D6R9Z0
ENSG00000120251	ENST00000506284	D6RFM6
ENSG00000120251	ENST00000507898	P42262
ENSG00000120251	ENST00000509417	D6RDX5
ENSG00000120251	ENST00000510854	H0Y972
ENSG00000120251	ENST00000512774	D6RBV7
ENSG00000120251	ENST00000645636	P42262

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Long-term potentiation	KEGG	ko04720
Long-term depression	KEGG	ko04730
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Long-term potentiation	KEGG	hsa04720
Long-term depression	KEGG	hsa04730
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Nicotine addiction	KEGG	hsa05033
Nicotine addiction	KEGG	ko05033
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Trafficking of GluR2-containing AMPA receptors	REACTOME	R-HSA-416993
Activation of AMPA receptors	REACTOME	R-HSA-399710
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activation	REACTOME	R-HSA-438066

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32581155	2020	Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.	2
32581155	2020	Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.	2
31053408	2019	Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.	16
31300657	2019	AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.	100
31454362	2019	Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives.	7
31053408	2019	Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.	16
31300657	2019	AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.	100
31454362	2019	Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives.	7
29339535	2018	Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome.	33
29618004	2018	The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.	16
29339535	2018	Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome.	33
29618004	2018	The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.	16
28195308	2017	Ca(2+) -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma.	7
28608743	2017	Obsessive-compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology.	7
28195308	2017	Ca(2+) -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma.	7

Citation

Dessen P

GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52897/gria2-(glutamate-ionotropic-receptor-ampa-type-subunit-2)