STIM2 (stromal interaction molecule 2)

2012-10-01  

Identity

HGNC
STIM2
LOCATION
4p15.2
LOCUSID
57620
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57620
MIM: 610841
HGNC: 19205
Ensembl: ENSG00000109689

Variants:

dbSNP: 57620
ClinVar: 57620
TCGA: ENSG00000109689
COSMIC: STIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109689ENST00000463501R4GMP0
ENSG00000109689ENST00000465503H0Y860
ENSG00000109689ENST00000467011H7C5A5
ENSG00000109689ENST00000467087A0A1X7SBY3
ENSG00000109689ENST00000473519H7C5K2
ENSG00000109689ENST00000477474H7C5C6
ENSG00000109689ENST00000478049R4GNC5
ENSG00000109689ENST00000494628R4GN82

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382342112024STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells.0
382342112024STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells.0
350222382022Functional communication between IP(3)R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE.14
358182142022STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-β1 pathway.2
350222382022Functional communication between IP(3)R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE.14
358182142022STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-β1 pathway.2
320129222020Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration.3
321869322020Notch enhances Ca(2+) entry by activating calcium-sensing receptors and inhibiting voltage-gated K(+) channels.13
325769322020Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry.3
326011882020STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca(2+) entry with NFAT1 activation.16
326415032020L-type Ca(2+) channel blockers promote vascular remodeling through activation of STIM proteins.25
327945682020Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca2+ content in resting estrogen receptor-positive breast cancer cells.12
330279062020Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin.24
330860682020Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry.14
320129222020Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration.3

Citation

Dessen P

STIM2 (stromal interaction molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52904/stim2-(stromal-interaction-molecule-2)