Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5226
MIM: 172200
HGNC: 8891
Ensembl: ENSG00000142657
Variants:
dbSNP: 5226
ClinVar: 5226
TCGA: ENSG00000142657
COSMIC: PGD
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37071129 | 2023 | Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation. | 0 |
| 37071129 | 2023 | Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation. | 0 |
| 32719331 | 2020 | HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors. | 14 |
| 32829780 | 2020 | 6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming. | 6 |
| 32719331 | 2020 | HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors. | 14 |
| 32829780 | 2020 | 6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming. | 6 |
| 30182212 | 2019 | Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1. | 14 |
| 30182212 | 2019 | Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1. | 14 |
| 29534964 | 2018 | Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming. | 17 |
| 29534964 | 2018 | Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming. | 17 |
| 26479318 | 2015 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. | 118 |
| 26479318 | 2015 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. | 118 |
| 24125036 | 2014 | 1p36.22 region containing PGD gene is frequently gained in human cervical cancer. | 2 |
| 25042803 | 2014 | Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. | 58 |
| 24125036 | 2014 | 1p36.22 region containing PGD gene is frequently gained in human cervical cancer. | 2 |
Citation
Dessen P
PGD (phosphogluconate dehydrogenase)
Atlas Genet Cytogenet Oncol Haematol. 2012-10-01
Online version: http://atlasgeneticsoncology.org/gene/52911/pgd-(phosphogluconate-dehydrogenase)
