KIF6 (kinesin family member 6)

2012-11-01  

Identity

HGNC
KIF6
LOCATION
6p21.2
LOCUSID
221458
ALIAS
C6orf102,dJ1043E3.1,dJ137F1.4,dJ188D3.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221458
MIM: 613919
HGNC: 21202
Ensembl: ENSG00000164627

Variants:

dbSNP: 221458
ClinVar: 221458
TCGA: ENSG00000164627
COSMIC: KIF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164627ENST00000229913Q6ZMV9
ENSG00000164627ENST00000287152Q6ZMV9
ENSG00000164627ENST00000394362Q2MDE8
ENSG00000164627ENST00000441975Q5JRK0
ENSG00000164627ENST00000458470H0Y718
ENSG00000164627ENST00000538893F6VGH2

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134308647rosuvastatinChemicalClinicalAnnotationassociatedPD30304062
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483, 30304062
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD18222353, 18222355, 21458191, 30304062
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483, 30304062
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483, 30304062
PA451089pravastatinChemicalClinicalAnnotationassociatedPD18222353, 18222355, 20215968, 20403483
PA451363simvastatinChemicalClinicalAnnotationassociatedPD21458191, 30304062

References

Pubmed IDYearTitleCitations
382355222024Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.1
382355222024Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.1
368331792023KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.1
368331792023KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.1
353426902022Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography or Percutaneous Coronary Intervention.0
353426902022Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography or Percutaneous Coronary Intervention.0
328676072021Are KIF6 and APOE polymorphisms associated with power and endurance athletes?2
328676072021Are KIF6 and APOE polymorphisms associated with power and endurance athletes?2
293048152018Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.1
293048152018Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.1
292955552017Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.7
292955552017Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.7
269975312016Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.2
269975312016Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.2
264432502015Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.4

Citation

Dessen P

KIF6 (kinesin family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52959/kif6-(kinesin-family-member-6)