CABIN1 (calcineurin binding protein 1)

2012-11-01  

Identity

HGNC
LOCATION
22q11.23
LOCUSID
ALIAS
CAIN,KB-318B8.7,PPP3IN
FUSION GENES

Other Information

Locus ID:

NCBI: 23523
MIM: 604251
HGNC: 24187
Ensembl: ENSG00000099991

Variants:

dbSNP: 23523
ClinVar: 23523
TCGA: ENSG00000099991
COSMIC: CABIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099991ENST00000263119Q9Y6J0
ENSG00000099991ENST00000263119A0A024R1E5
ENSG00000099991ENST00000337989B5MEB3
ENSG00000099991ENST00000398319Q9Y6J0
ENSG00000099991ENST00000398319A0A024R1E5
ENSG00000099991ENST00000405822Q9Y6J0
ENSG00000099991ENST00000445422C9J068
ENSG00000099991ENST00000454754C9JT60
ENSG00000099991ENST00000617531A0A087WWW8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
127007642003Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2.40
218078932011Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.28
236245252013Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.18
150637622004Genetic variations in humans associated with differences in the course of hepatitis C.16
224013102012Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.16
196682102009Cabin1 restrains p53 activity on chromatin.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
197175612009Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.10

Citation

Dessen P

CABIN1 (calcineurin binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52975/cabin1-(calcineurin-binding-protein-1)