CAPRIN1 (cell cycle associated protein 1)

2012-11-01 Affiliation

Identity

HGNC

CAPRIN1

LOCATION

11p13

LOCUSID

4076

ALIAS

GPIAP1,GPIP137,GRIP137,M11S1,RNG105,p137GPI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4076
MIM: 601178
HGNC: 6743
Ensembl: ENSG00000135387

Variants:

dbSNP: 4076
ClinVar: 4076
TCGA: ENSG00000135387
COSMIC: CAPRIN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135387	ENST00000341394	Q14444
ENSG00000135387	ENST00000389645	Q14444
ENSG00000135387	ENST00000529307	G3V153
ENSG00000135387	ENST00000530820	Q14444
ENSG00000135387	ENST00000532820	Q14444
ENSG00000135387	ENST00000534825	E9PLA9

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
27022092	2016	G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.	114
17210633	2007	Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs.	100
24992036	2014	G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.	96
25784705	2015	Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.	45
15471883	2004	Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer.	43
23097442	2013	Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.	38
19250063	2009	Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation.	31
16177067	2005	Absence of caprin-1 results in defects in cellular proliferation.	28
22737234	2012	Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].	26
14764709	2004	Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.	25

Citation

Dessen P

CAPRIN1 (cell cycle associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52977/caprin1-(cell-cycle-associated-protein-1)