LONP1 (lon peptidase 1, mitochondrial)

2012-11-01  

Identity

HGNC
LONP1
LOCATION
19p13.3
LOCUSID
9361
ALIAS
CODASS,LON,LONP,LonHS,PIM1,PRSS15,hLON
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9361
MIM: 605490
HGNC: 9479
Ensembl: ENSG00000196365

Variants:

dbSNP: 9361
ClinVar: 9361
TCGA: ENSG00000196365
COSMIC: LONP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196365ENST00000360614P36776
ENSG00000196365ENST00000540670P36776
ENSG00000196365ENST00000585374K7EKE6
ENSG00000196365ENST00000586617K7ERS1
ENSG00000196365ENST00000587365K7ER56
ENSG00000196365ENST00000589473K7ERR6
ENSG00000196365ENST00000590206K7ER27
ENSG00000196365ENST00000590558K7EQF8
ENSG00000196365ENST00000590729K7EJE8
ENSG00000196365ENST00000593119P36776

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365089082023Inhibition of Lonp1 induces mitochondrial remodeling and autophagy suppression in cervical cancer cells.1
366290482023LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.6
367394372023Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination.2
376478042023Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis.0
380912892023Intraneuronal β-amyloid impaired mitochondrial proteostasis through the impact on LONP1.2
365089082023Inhibition of Lonp1 induces mitochondrial remodeling and autophagy suppression in cervical cancer cells.1
366290482023LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.6
367394372023Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination.2
376478042023Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis.0
380912892023Intraneuronal β-amyloid impaired mitochondrial proteostasis through the impact on LONP1.2
358704502022Catalytic cycling of human mitochondrial Lon protease.6
360640702022LONP1 downregulation with ageing contributes to osteoarthritis via mitochondrial dysfunction.6
363621582022Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight.1
364971972022Differential Expression of Lonp1 Isoforms in Cancer Cells.4
358704502022Catalytic cycling of human mitochondrial Lon protease.6

Citation

Dessen P

LONP1 (lon peptidase 1, mitochondrial)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53020/lonp1-(lon-peptidase-1-mitochondrial)