NOP2 (NOP2 nucleolar protein)

2012-11-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
NOL1,NOP120,NSUN1,p120
FUSION GENES

Other Information

Locus ID:

NCBI: 4839
MIM: 164031
HGNC: 7867
Ensembl: ENSG00000111641

Variants:

dbSNP: 4839
ClinVar: 4839
TCGA: ENSG00000111641
COSMIC: NOP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111641ENST00000322166P46087
ENSG00000111641ENST00000382421P46087
ENSG00000111641ENST00000399466P46087
ENSG00000111641ENST00000536124F5H709
ENSG00000111641ENST00000537442P46087
ENSG00000111641ENST00000538420F5H8G6
ENSG00000111641ENST00000540228F5H359
ENSG00000111641ENST00000541778P46087
ENSG00000111641ENST00000542867F5H5X6
ENSG00000111641ENST00000542944F5GYR3
ENSG00000111641ENST00000545200P46087
ENSG00000111641ENST00000545492F5GWB7
ENSG00000111641ENST00000545915F5H359
ENSG00000111641ENST00000617555P46087
ENSG00000111641ENST00000620535P46087

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiationREACTOMER-HSA-8869496
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
261961252015Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.19
254814152015Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain.7
269064242016Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1.4
321767342020Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation.0

Citation

Dessen P

NOP2 (NOP2 nucleolar protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53027/nop2-(nop2-nucleolar-protein)