ADORA2B (adenosine A2b receptor)

2012-12-01  

Identity

HGNC
LOCATION
17p12
LOCUSID
ALIAS
ADORA2
FUSION GENES

Other Information

Locus ID:

NCBI: 136
MIM: 600446
HGNC: 264
Ensembl: ENSG00000170425

Variants:

dbSNP: 136
ClinVar: 136
TCGA: ENSG00000170425
COSMIC: ADORA2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170425ENST00000304222P29275

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Metabolism of proteinsREACTOMER-HSA-392499
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Surfactant metabolismREACTOMER-HSA-5683826

References

Pubmed IDYearTitleCitations
129393452003Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.218
180568392008A2B adenosine receptor dampens hypoxia-induced vascular leak.140
170773012006HIF-dependent induction of adenosine A2B receptor in hypoxia.124
225044832012Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.110
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126008792003Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.68
234830552013Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.58
151871562004Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.54
215907342011Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes.49
212425132011A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice.41

Citation

Dessen P

ADORA2B (adenosine A2b receptor)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53079/adora2b-(adenosine-a2b-receptor)