Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
AES,AES-1,AES-2,ESP1,GRG,GRG5,Grg-5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 166
MIM: 600188
HGNC: 307
Ensembl: ENSG00000104964
Variants:
dbSNP: 166
ClinVar: 166
TCGA: ENSG00000104964
COSMIC: TLE5
RNA/Proteins
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37800625 | 2023 | Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α. | 2 |
| 37800625 | 2023 | Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α. | 2 |
| 33754069 | 2021 | The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. | 12 |
| 33754069 | 2021 | The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. | 12 |
| 28178391 | 2017 | Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer. | 13 |
| 28178391 | 2017 | Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer. | 13 |
| 26229111 | 2016 | Characterization of Aes nuclear foci in colorectal cancer cells. | 5 |
| 27561171 | 2016 | Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. | 12 |
| 26229111 | 2016 | Characterization of Aes nuclear foci in colorectal cancer cells. | 5 |
| 27561171 | 2016 | Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. | 12 |
| 26549228 | 2015 | Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES). | 3 |
| 26549228 | 2015 | Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES). | 3 |
| 23546594 | 2013 | Suppression of RND3 activity by AES downregulation promotes cancer cell proliferation and invasion. | 9 |
| 23732115 | 2013 | A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression. | 0 |
| 23840876 | 2013 | GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. | 8 |
Citation
Dessen P
TLE5 (TLE family member 5, transcriptional modulator)
Atlas Genet Cytogenet Oncol Haematol. 2012-12-01
Online version: http://atlasgeneticsoncology.org/gene/53080/tle5-(tle-family-member-5-transcriptional-modulator)
