ADORA3 (adenosine A3 receptor)

2012-12-01  

Identity

HGNC
ADORA3
LOCATION
1p13.2
LOCUSID
140
ALIAS
A3AR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 140
MIM: 600445
HGNC: 268
Ensembl: ENSG00000282608

Variants:

dbSNP: 140
ClinVar: 140
TCGA: ENSG00000282608
COSMIC: ADORA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000282608ENST00000241356P0DMS8
ENSG00000282608ENST00000632535A0A0J9YWR0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
387152832024Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury.1
387152832024Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury.1
334203532021Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells.4
334720582021N(6)-methyladenosine (m(6)A) is an endogenous A3 adenosine receptor ligand.24
335247702021Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.4
343607192021Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A(3) Receptor Subtype.16
334203532021Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells.4
334720582021N(6)-methyladenosine (m(6)A) is an endogenous A3 adenosine receptor ligand.24
335247702021Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.4
343607192021Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A(3) Receptor Subtype.16
324488692020Analysis of association of ADORA(2)A and ADORA(3) polymorphisms genotypes/haplotypes with efficacy and toxicity of methotrexate in patients with Rheumatoid arthritis.2
327091032020Adenosine A(2A) and A(3) Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling.9
330078352020Activation of Adenosine A(3) Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure.11
324488692020Analysis of association of ADORA(2)A and ADORA(3) polymorphisms genotypes/haplotypes with efficacy and toxicity of methotrexate in patients with Rheumatoid arthritis.2
327091032020Adenosine A(2A) and A(3) Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling.9

Citation

Dessen P

ADORA3 (adenosine A3 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53089/adora3-(adenosine-a3-receptor)