ADORA3 (adenosine A3 receptor)

2012-12-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
A3AR
FUSION GENES

Other Information

Locus ID:

NCBI: 140
MIM: 600445
HGNC: 268
Ensembl: ENSG00000282608

Variants:

dbSNP: 140
ClinVar: 140
TCGA: ENSG00000282608
COSMIC: ADORA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000282608ENST00000241356P0DMS8
ENSG00000282608ENST00000632535A0A0J9YWR0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
171703102006ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.325
168495092006The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126008792003Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
152405392004The A3 adenosine receptor is highly expressed in tumor versus normal cells: potential target for tumor growth inhibition.53
186361492008The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-kappaB signal transduction pathways.43
194269662009The anti-inflammatory target A(3) adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn's disease.40
217156802011Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.38
118912212002Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor.37

Citation

Dessen P

ADORA3 (adenosine A3 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53089/adora3-(adenosine-a3-receptor)