ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)

2012-12-01 Affiliation

Identity

HGNC

ADH1A

LOCATION

4q23

LOCUSID

124

ALIAS

ADH1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 124
MIM: 103700
HGNC: 249
Ensembl: ENSG00000187758

Variants:

dbSNP: 124
ClinVar: 124
TCGA: ENSG00000187758
COSMIC: ADH1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187758	ENST00000209668	P07327

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycolysis / Gluconeogenesis	KEGG	ko00010
Fatty acid degradation	KEGG	ko00071
Tyrosine metabolism	KEGG	ko00350
Retinol metabolism	KEGG	ko00830
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Glycolysis / Gluconeogenesis	KEGG	hsa00010
Fatty acid degradation	KEGG	hsa00071
Tyrosine metabolism	KEGG	hsa00350
Retinol metabolism	KEGG	hsa00830
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Retinoic Acid	REACTOME	R-HSA-5362517
RA biosynthesis pathway	REACTOME	R-HSA-5365859
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Ethanol oxidation	REACTOME	R-HSA-71384
Abacavir transport and metabolism	REACTOME	R-HSA-2161522
Abacavir metabolism	REACTOME	R-HSA-2161541

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PMIDs
PA166155185	rs1234612	Variant	VipGene	associated
PA166156497	rs975833	Variant	VipGene	associated
PA166186245	acetaldehyde	Chemical	ClinicalAnnotation	associated	PK	31002879
PA443309	Alcoholism	Disease	VipGene	associated
PA448004	abacavir	Chemical	Pathway	associated		24625462
PA448073	ethanol	Chemical	VipGene	associated

References

Pubmed ID	Year	Title	Citations
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16685648	2006	Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.	63
18331377	2008	Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.	43
19193628	2009	ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.	33
19193628	2009	ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.	33
19687126	2009	A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.	30
17185388	2007	Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.	25
19124506	2009	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	22
24762066	2014	Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer.	21

Citation

Dessen P

ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53093/adh1a-(alcohol-dehydrogenase-1a-(class-i)-alpha-polypeptide)