AKAP13 (A-kinase anchoring protein 13)

2012-12-01  

Identity

HGNC
AKAP13
LOCATION
15q25.3
LOCUSID
11214
ALIAS
AKAP-13,AKAP-Lbc,ARHGEF13,BRX,HA-3,Ht31,LBC,PRKA13,PROTO-LB,PROTO-LBC,c-lbc,p47
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11214
MIM: 604686
HGNC: 371
Ensembl: ENSG00000170776

Variants:

dbSNP: 11214
ClinVar: 11214
TCGA: ENSG00000170776
COSMIC: AKAP13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170776ENST00000361243Q12802
ENSG00000170776ENST00000394510A8MYJ1
ENSG00000170776ENST00000394518Q12802
ENSG00000170776ENST00000557852A0A087WX73
ENSG00000170776ENST00000558166H0YK18
ENSG00000170776ENST00000558811H0YK84
ENSG00000170776ENST00000559362H0YMW2
ENSG00000170776ENST00000559486H0YLH1
ENSG00000170776ENST00000560256H0YMI5
ENSG00000170776ENST00000560302Q12802
ENSG00000170776ENST00000560340A0A087X047
ENSG00000170776ENST00000560579A0A087WTD7
ENSG00000170776ENST00000560676A0A087WY36
ENSG00000170776ENST00000612418A0A087WYS7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
364010722023AKAP13 Enhances CREB1 Activation by FSH in Granulosa Cells.1
364010722023AKAP13 Enhances CREB1 Activation by FSH in Granulosa Cells.1
355600092022The role of Hippo pathway signaling and A-kinase anchoring protein 13 in primordial follicle activation and inhibition.3
355600092022The role of Hippo pathway signaling and A-kinase anchoring protein 13 in primordial follicle activation and inhibition.3
334062632021CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation.4
346737742021AKAP13 couples GPCR signaling to mTORC1 inhibition.9
334062632021CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation.4
346737742021AKAP13 couples GPCR signaling to mTORC1 inhibition.9
322088712020Prognostic value of AKAP13 methylation and expression in lung squamous cell carcinoma.4
322088712020Prognostic value of AKAP13 methylation and expression in lung squamous cell carcinoma.4
302398312019A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells.7
314694032019Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy.14
302398312019A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells.7
314694032019Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy.14
289232492017AKAP-Lbc mediates protection against doxorubicin-induced cardiomyocyte toxicity.11

Citation

Dessen P

AKAP13 (A-kinase anchoring protein 13)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53096/js/lib/deep-insight-explorer/hgnc