ALDH1A3 (aldehyde dehydrogenase 1 family member A3)

2012-12-01  

Identity

HGNC
ALDH1A3
LOCATION
15q26.3
LOCUSID
220
ALIAS
ALDH1A6,ALDH6,MCOP8,RALDH3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 220
MIM: 600463
HGNC: 409
Ensembl: ENSG00000184254

Variants:

dbSNP: 220
ClinVar: 220
TCGA: ENSG00000184254
COSMIC: ALDH1A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184254ENST00000329841P47895
ENSG00000184254ENST00000329841A0A024RC95
ENSG00000184254ENST00000346623H0Y2X5
ENSG00000184254ENST00000557963H0YLT1
ENSG00000184254ENST00000558033H0YNQ3
ENSG00000184254ENST00000561338H0YKF9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Histidine metabolismKEGGko00340
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
beta-Alanine metabolismKEGGko00410
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Histidine metabolismKEGGhsa00340
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
beta-Alanine metabolismKEGGhsa00410
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372490632024METTL3-mediated ALDH m(6)A methylation regulates the malignant behavior of BMI1(+) HNSCC stem cells.3
377537402024ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.0
372490632024METTL3-mediated ALDH m(6)A methylation regulates the malignant behavior of BMI1(+) HNSCC stem cells.3
377537402024ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.0
369964942023MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3.3
369976792023Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia.1
379476012023Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.3
369964942023MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3.3
369976792023Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia.1
379476012023Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.3
354182002022Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.3
355986582022Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis.4
357902832022High Expression of p62 and ALDH1A3 Is Associated With Poor Prognosis in Luminal B Breast Cancer.5
362888782022High Expression of CD58 and ALDH1A3 Predicts a Poor Prognosis in Basal-like Breast Cancer.5
354182002022Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.3

Citation

Dessen P

ALDH1A3 (aldehyde dehydrogenase 1 family member A3)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53102/aldh1a3-(aldehyde-dehydrogenase-1-family-member-a3)