AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1)

2012-12-01  

Identity

HGNC
AIMP1
LOCATION
4q24
LOCUSID
9255
ALIAS
EMAP2,EMAPII,HLD3,SCYE1,p43
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9255
MIM: 603605
HGNC: 10648
Ensembl: ENSG00000164022

Variants:

dbSNP: 9255
ClinVar: 9255
TCGA: ENSG00000164022
COSMIC: AIMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164022ENST00000358008Q12904
ENSG00000164022ENST00000394701Q12904
ENSG00000164022ENST00000442366Q12904
ENSG00000164022ENST00000510207D6R937

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
SeMet incorporation into proteinsREACTOMER-HSA-2408517

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
215768222011Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice.39
210929222010Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation.31
190021092009Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling.27
199176872009Deciphering the immune function and regulation by a TLR of the cytokine EMAPII in the lesioned central nervous system using a leech model.14
252887752014Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation.14
125430782002Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43.13
166749412006Identification of protease-sensitive sites in Human Endothelial-Monocyte Activating Polypeptide II protein.11
193625502009Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.10
149829442004Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis.9
159359552005Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells.9

Citation

Dessen P

AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53103/aimp1-(aminoacyl-trna-synthetase-complex-interacting-multifunctional-protein-1)