Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 91607
MIM: 614953
HGNC: 26633
Ensembl: ENSG00000172716
Variants:
dbSNP: 91607
ClinVar: 91607
TCGA: ENSG00000172716
COSMIC: SLFN11
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA150481186 | topoisomerase I inhibitors | Chemical | MultilinkAnnotation | associated | 26555224 | ||
| PA445597 | Sarcoma, Ewing's | Disease | MultilinkAnnotation | associated | 26555224 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38206539 | 2024 | SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway. | 1 |
| 38875319 | 2024 | Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA. | 1 |
| 38206539 | 2024 | SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway. | 1 |
| 38875319 | 2024 | Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA. | 1 |
| 37833372 | 2023 | Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response. | 1 |
| 37833372 | 2023 | Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response. | 1 |
| 34893686 | 2022 | FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11. | 6 |
| 35105802 | 2022 | Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. | 14 |
| 35440668 | 2022 | Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer. | 6 |
| 36115853 | 2022 | Mechanistic understanding of human SLFN11. | 15 |
| 36382088 | 2022 | SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression. | 2 |
| 34893686 | 2022 | FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11. | 6 |
| 35105802 | 2022 | Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. | 14 |
| 35440668 | 2022 | Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer. | 6 |
| 36115853 | 2022 | Mechanistic understanding of human SLFN11. | 15 |
Citation
Dessen P
SLFN11 (schlafen family member 11)
Atlas Genet Cytogenet Oncol Haematol. 2013-01-01
Online version: http://atlasgeneticsoncology.org/gene/53135/slfn11-(schlafen-family-member-11)
