Identity
HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
C22orf12,DGCRK6,Gy1,pasha
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54487
MIM: 609030
HGNC: 2847
Ensembl: ENSG00000128191
Variants:
dbSNP: 54487
ClinVar: 54487
TCGA: ENSG00000128191
COSMIC: DGCR8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000128191 | ENST00000351989 | Q8WYQ5 |
| ENSG00000128191 | ENST00000383024 | Q8WYQ5 |
| ENSG00000128191 | ENST00000407755 | Q8WYQ5 |
| ENSG00000128191 | ENST00000457069 | C9JSD5 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Gene Silencing by RNA | REACTOME | R-HSA-211000 |
| MicroRNA (miRNA) biogenesis | REACTOME | R-HSA-203927 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38252873 | 2024 | Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules. | 3 |
| 38252873 | 2024 | Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules. | 3 |
| 36811004 | 2023 | Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. | 4 |
| 36950067 | 2023 | The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8. | 4 |
| 36811004 | 2023 | Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. | 4 |
| 36950067 | 2023 | The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8. | 4 |
| 36068012 | 2022 | METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8. | 6 |
| 36360162 | 2022 | Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene. | 0 |
| 36068012 | 2022 | METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8. | 6 |
| 36360162 | 2022 | Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene. | 0 |
| 33581109 | 2021 | DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2. | 7 |
| 34171097 | 2021 | Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8. | 13 |
| 34188037 | 2021 | Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. | 9 |
| 34273915 | 2021 | Pathogenic noncoding variants in the neurofibromatosis and schwannomatosis predisposition genes. | 1 |
| 34319763 | 2021 | Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis. | 3 |
Citation
Dessen P
DGCR8 (DGCR8 microprocessor complex subunit)
Atlas Genet Cytogenet Oncol Haematol. 2013-01-01
Online version: http://atlasgeneticsoncology.org/gene/53138
