Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2342
MIM: 134636
HGNC: 3785
Ensembl: ENSG00000257365
Variants:
dbSNP: 2342
ClinVar: 2342
TCGA: ENSG00000257365
COSMIC: FNTB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000257365 | ENST00000246166 | P49356 |
| ENSG00000257365 | ENST00000246166 | A0A384MEJ5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166129466 | lonafarnib | Chemical | ClinicalAnnotation | associated | PD | 26033044 | |
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation | associated | PD | 26033044 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 26033044 | |
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation | associated | PD | 26033044 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35167937 | 2022 | Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression. | 1 |
| 35167937 | 2022 | Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression. | 1 |
| 34315531 | 2021 | Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. | 12 |
| 34315531 | 2021 | Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. | 12 |
| 23643986 | 2013 | Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. | 0 |
| 23643986 | 2013 | Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. | 0 |
| 22882915 | 2012 | Expression of farnesyltransferase in primary liver cancer. | 2 |
| 22992747 | 2012 | Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. | 9 |
| 22882915 | 2012 | Expression of farnesyltransferase in primary liver cancer. | 2 |
| 22992747 | 2012 | Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. | 9 |
| 19841875 | 2010 | Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. | 2 |
| 19841875 | 2010 | Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. | 2 |
| 11751396 | 2001 | Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. | 67 |
| 11751396 | 2001 | Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. | 67 |
Citation
Dessen P
FNTB (farnesyltransferase, CAAX box, beta)
Atlas Genet Cytogenet Oncol Haematol. 2013-01-01
Online version: http://atlasgeneticsoncology.org/gene/53141/fntb-(farnesyltransferase-caax-box-beta)
