FNTB (farnesyltransferase, CAAX box, beta)

2013-01-01 Affiliation

Identity

HGNC

FNTB

LOCATION

14q23.3

LOCUSID

2342

ALIAS

FPTB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2342
MIM: 134636
HGNC: 3785
Ensembl: ENSG00000257365

Variants:

dbSNP: 2342
ClinVar: 2342
TCGA: ENSG00000257365
COSMIC: FNTB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000257365	ENST00000246166	P49356
ENSG00000257365	ENST00000246166	A0A384MEJ5

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Terpenoid backbone biosynthesis	KEGG	ko00900
Terpenoid backbone biosynthesis	KEGG	hsa00900
Signal Transduction	REACTOME	R-HSA-162582
Visual phototransduction	REACTOME	R-HSA-2187338
The phototransduction cascade	REACTOME	R-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA166129466	lonafarnib	Chemical	ClinicalAnnotation	associated	PD	26033044
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation	associated	PD	26033044
PA448803	carboplatin	Chemical	ClinicalAnnotation	associated	PD	26033044
PA450761	paclitaxel	Chemical	ClinicalAnnotation	associated	PD	26033044

References

Pubmed ID	Year	Title	Citations
35167937	2022	Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression.	1
35167937	2022	Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression.	1
34315531	2021	Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.	12
34315531	2021	Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.	12
23643986	2013	Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells.	0
23643986	2013	Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells.	0
22882915	2012	Expression of farnesyltransferase in primary liver cancer.	2
22992747	2012	Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.	9
22882915	2012	Expression of farnesyltransferase in primary liver cancer.	2
22992747	2012	Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.	9
19841875	2010	Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.	2
19841875	2010	Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.	2
11751396	2001	Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.	67
11751396	2001	Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.	67

Citation

Dessen P

FNTB (farnesyltransferase, CAAX box, beta)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53141/fntb-(farnesyltransferase-caax-box-beta)