CA1 (carbonic anhydrase 1)

2013-02-01  

Identity

HGNC
CA1
LOCATION
8q21.2
LOCUSID
759
ALIAS
CA-I,CAB,Car1,HEL-S-11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 759
MIM: 114800
HGNC: 1368
Ensembl: ENSG00000133742

Variants:

dbSNP: 759
ClinVar: 759
TCGA: ENSG00000133742
COSMIC: CA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133742ENST00000431316P00915
ENSG00000133742ENST00000431316V9HWE3
ENSG00000133742ENST00000517429E5RII2
ENSG00000133742ENST00000517590E5RH81
ENSG00000133742ENST00000517618E5RHP7
ENSG00000133742ENST00000519129E5RHS7
ENSG00000133742ENST00000519991E5RJI8
ENSG00000133742ENST00000520663E5RJF6
ENSG00000133742ENST00000521679H0YBE2
ENSG00000133742ENST00000521846E5RG43
ENSG00000133742ENST00000522389E5RG81
ENSG00000133742ENST00000522579E5RG43
ENSG00000133742ENST00000522662E5RFL2
ENSG00000133742ENST00000522814E5RIF9
ENSG00000133742ENST00000523022P00915
ENSG00000133742ENST00000523022V9HWE3
ENSG00000133742ENST00000523858E5RGU8
ENSG00000133742ENST00000523953P00915
ENSG00000133742ENST00000523953V9HWE3
ENSG00000133742ENST00000524324E5RFE7
ENSG00000133742ENST00000542576P00915
ENSG00000133742ENST00000542576V9HWE3
ENSG00000133742ENST00000626824E5RG81

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Nitrogen metabolismKEGGko00910
Nitrogen metabolismKEGGhsa00910
MetabolismREACTOMER-HSA-1430728
O2/CO2 exchange in erythrocytesREACTOMER-HSA-1480926
Erythrocytes take up carbon dioxide and release oxygenREACTOMER-HSA-1237044
Erythrocytes take up oxygen and release carbon dioxideREACTOMER-HSA-1247673
Reversible hydration of carbon dioxideREACTOMER-HSA-1475029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
336829382021Carbonic anhydrase activity in the frontal lobe of human brain.1
336829382021Carbonic anhydrase activity in the frontal lobe of human brain.1
319636972020Overexpression of CA1 mRNA and the CA I Protein in Tumor Cells Does Not Change the Gene Expression of the ECM Proteins.1
320318912020Comprehensive Analysis for Identifying Diagnostic and Prognostic Biomarkers in Colon Adenocarcinoma.6
329927972020The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II.5
319636972020Overexpression of CA1 mRNA and the CA I Protein in Tumor Cells Does Not Change the Gene Expression of the ECM Proteins.1
320318912020Comprehensive Analysis for Identifying Diagnostic and Prognostic Biomarkers in Colon Adenocarcinoma.6
329927972020The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II.5
309164662019Silencing of carbonic anhydrase I enhances the malignant potential of exosomes secreted by prostatic tumour cells.3
309164662019Silencing of carbonic anhydrase I enhances the malignant potential of exosomes secreted by prostatic tumour cells.3
287829092018Silencing of CA1 mRNA in tumour cells does not change the gene expression of the extracellular matrix proteins.3
287829092018Silencing of CA1 mRNA in tumour cells does not change the gene expression of the extracellular matrix proteins.3
282703702017Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia.3
284450012017Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes.4
285443592017Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base.0

Citation

Dessen P

CA1 (carbonic anhydrase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53151/ca1-(carbonic-anhydrase-1)