SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3)

2013-02-01  

Identity

HGNC
SH3GL3
LOCATION
15q25.2
LOCUSID
6457
ALIAS
CNSA3,EEN-B2,HsT19371,SH3D2C,SH3P13
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6457
MIM: 603362
HGNC: 10832
Ensembl: ENSG00000140600

Variants:

dbSNP: 6457
ClinVar: 6457
TCGA: ENSG00000140600
COSMIC: SH3GL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140600ENST00000324537Q99963
ENSG00000140600ENST00000427482Q99963
ENSG00000140600ENST00000563901H3BRH8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Signaling by METREACTOMER-HSA-6806834
Negative regulation of MET activityREACTOMER-HSA-6807004
Listeria monocytogenes entry into host cellsREACTOMER-HSA-8876384
InlB-mediated entry of Listeria monocytogenes into host cellREACTOMER-HSA-8875360

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379167312023LncRNA MIR210HG promotes the proliferation, migration, and invasion of lung cancer cells by inhibiting the transcription of SH3GL3.0
379167312023LncRNA MIR210HG promotes the proliferation, migration, and invasion of lung cancer cells by inhibiting the transcription of SH3GL3.0
331681852021SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner.5
335248712021SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling.2
331681852021SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner.5
335248712021SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling.2
321933812020Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166.35
321933812020Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166.35
276830322016The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance.7
276830322016The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance.7
217221562012Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes.27
229011472012Genome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients.10
217221562012Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes.27
229011472012Genome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients.10
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.28

Citation

Dessen P

SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53167/sh3gl3-(sh3-domain-containing-grb2-like-3-endophilin-a3)