Identity
HGNC
LOCATION
12q14.3
LOCUSID
ALIAS
TIP120,TIP120A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55832
MIM: 607727
HGNC: 30688
Ensembl: ENSG00000111530
Variants:
dbSNP: 55832
ClinVar: 55832
TCGA: ENSG00000111530
COSMIC: CAND1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111530 | ENST00000540319 | H0YH27 |
| ENSG00000111530 | ENST00000540525 | F5H6I6 |
| ENSG00000111530 | ENST00000544619 | A0A0C4DGH5 |
| ENSG00000111530 | ENST00000545606 | Q86VP6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37028429 | 2023 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. | 7 |
| 37339624 | 2023 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. | 3 |
| 38148115 | 2023 | ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3. | 2 |
| 37028429 | 2023 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. | 7 |
| 37339624 | 2023 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. | 3 |
| 38148115 | 2023 | ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3. | 2 |
| 35661710 | 2022 | Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation. | 2 |
| 35661710 | 2022 | Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation. | 2 |
| 31511573 | 2019 | CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. | 5 |
| 31511573 | 2019 | CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. | 5 |
| 28871425 | 2018 | miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. | 15 |
| 28871425 | 2018 | miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. | 15 |
| 28388044 | 2017 | Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements. | 10 |
| 28388044 | 2017 | Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements. | 10 |
| 26219975 | 2015 | CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis. | 9 |
Citation
Dessen P
CAND1 (cullin associated and neddylation dissociated 1)
Atlas Genet Cytogenet Oncol Haematol. 2013-02-01
Online version: http://atlasgeneticsoncology.org/gene/53172/cand1-(cullin-associated-and-neddylation-dissociated-1)
