DAO (D-amino acid oxidase)

2013-02-01  

Identity

HGNC
DAO
LOCATION
12q24.11
LOCUSID
1610
ALIAS
DAAO,DAMOX,OXDA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1610
MIM: 124050
HGNC: 2671
Ensembl: ENSG00000110887

Variants:

dbSNP: 1610
ClinVar: 1610
TCGA: ENSG00000110887
COSMIC: DAO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110887ENST00000228476P14920
ENSG00000110887ENST00000228476A0A024RBI1
ENSG00000110887ENST00000547122A0A0B4J257
ENSG00000110887ENST00000547166F8W152
ENSG00000110887ENST00000547768F8VV35
ENSG00000110887ENST00000549215F8VVT2
ENSG00000110887ENST00000551281A0A0B4J250

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Arginine and proline metabolismKEGGko00330
D-Arginine and D-ornithine metabolismKEGGko00472
Glycine, serine and threonine metabolismKEGGhsa00260
Arginine and proline metabolismKEGGhsa00330
D-Arginine and D-ornithine metabolismKEGGhsa00472
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381345632024Aggregation of E121K mutant D-amino acid oxidase and ubiquitination-mediated autophagy mechanisms leading to amyotrophic lateral sclerosis.0
381345632024Aggregation of E121K mutant D-amino acid oxidase and ubiquitination-mediated autophagy mechanisms leading to amyotrophic lateral sclerosis.0
375581092023Characterization of E121K mutation of D-amino acid oxidase - Insights into mechanisms leading to amyotrophic lateral sclerosis.0
375581092023Characterization of E121K mutation of D-amino acid oxidase - Insights into mechanisms leading to amyotrophic lateral sclerosis.0
349839732022Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.0
354306322022Blood D-Amino Acid Oxidase Levels Increased With Cognitive Decline Among People With Mild Cognitive Impairment: A Two-Year Prospective Study.4
349839732022Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.0
354306322022Blood D-Amino Acid Oxidase Levels Increased With Cognitive Decline Among People With Mild Cognitive Impairment: A Two-Year Prospective Study.4
324568982020Fabrication of a porous polymer membrane enzyme reactor and its enzymatic kinetics study in an artificial kidney model.1
326239172020Is the primate-specific protein pLG72 affecting SOD1 functionality and superoxide formation?1
327305632020P219L substitution in human D-amino acid oxidase impacts the ligand binding and catalytic efficiency.0
328182362020Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians.4
328241072020Histamine Intolerance: The Current State of the Art.67
329975592020Human diamine oxidase is readily released from activated neutrophils ex vivo and in vivo but is rarely elevated in bacteremic patients.0
330514922020Mechanistic insights into the loss-of-function mechanisms of rare human D-amino acid oxidase variants implicated in amyotrophic lateral sclerosis.2

Citation

Dessen P

DAO (D-amino acid oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53173/dao-(d-amino-acid-oxidase)