Identity
HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
HEL-S-66p,IOPPP,PP,PP1,SID6-8061
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5464
MIM: 179030
HGNC: 9226
Ensembl: ENSG00000180817
Variants:
dbSNP: 5464
ClinVar: 5464
TCGA: ENSG00000180817
COSMIC: PPA1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000180817 | ENST00000373230 | Q5SQT6 |
| ENSG00000180817 | ENST00000373232 | Q15181 |
| ENSG00000180817 | ENST00000373232 | V9HWB5 |
| ENSG00000180817 | ENST00000625364 | Q5SQT6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38428647 | 2024 | Structural and biochemical characterization of active sites mutant in human inorganic pyrophosphatase. | 0 |
| 38428647 | 2024 | Structural and biochemical characterization of active sites mutant in human inorganic pyrophosphatase. | 0 |
| 37141926 | 2023 | Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer. | 3 |
| 38136612 | 2023 | PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. | 0 |
| 37141926 | 2023 | Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer. | 3 |
| 38136612 | 2023 | PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. | 0 |
| 33537097 | 2021 | Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells. | 3 |
| 33583053 | 2021 | Crystallographic and modeling study of the human inorganic pyrophosphatase 1: A potential anti-cancer drug target. | 2 |
| 33991172 | 2021 | PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression. | 6 |
| 34634305 | 2021 | Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity. | 5 |
| 33537097 | 2021 | Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells. | 3 |
| 33583053 | 2021 | Crystallographic and modeling study of the human inorganic pyrophosphatase 1: A potential anti-cancer drug target. | 2 |
| 33991172 | 2021 | PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression. | 6 |
| 34634305 | 2021 | Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity. | 5 |
| 32755477 | 2020 | PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20. | 12 |
Citation
Dessen P
PPA1 (inorganic pyrophosphatase 1)
Atlas Genet Cytogenet Oncol Haematol. 2013-02-01
Online version: http://atlasgeneticsoncology.org/gene/53182/ppa1-(inorganic-pyrophosphatase-1)
