PTGR2 (prostaglandin reductase 2)

2013-02-01  

Identity

HGNC
PTGR2
LOCATION
14q24.3
LOCUSID
145482
ALIAS
HEL-S-298,PGR2,ZADH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 145482
MIM: 608642
HGNC: 20149
Ensembl: ENSG00000258653

Variants:

dbSNP: 145482
ClinVar: 145482
TCGA: ENSG00000258653
COSMIC: PTGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000258653ENST00000556551G3V3Y1

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123

References

Pubmed IDYearTitleCitations
268207382016Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2.14
268207382016Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2.14
229987752012Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients.5
229987752012Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients.5
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
190008232008Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2.22
190008232008Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2.22
150044682003Cloning and characterization of a novel splicing variant of the ZADH1 gene.1
150044682003Cloning and characterization of a novel splicing variant of the ZADH1 gene.1

Citation

Dessen P

PTGR2 (prostaglandin reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53191/ptgr2-(prostaglandin-reductase-2)