Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
CXXC2,FBXL10,Fbl10,JHDM1B,PCCX2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84678
MIM: 609078
HGNC: 13610
Ensembl: ENSG00000089094
Variants:
dbSNP: 84678
ClinVar: 84678
TCGA: ENSG00000089094
COSMIC: KDM2B
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37935302 | 2024 | Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4. | 2 |
| 38017132 | 2024 | The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma. | 0 |
| 37935302 | 2024 | Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4. | 2 |
| 38017132 | 2024 | The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma. | 0 |
| 36322151 | 2023 | Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature. | 4 |
| 37634866 | 2023 | KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma. | 0 |
| 37751135 | 2023 | Biological Functions of the KDM2 Family of Histone Demethylases. | 1 |
| 36322151 | 2023 | Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature. | 4 |
| 37634866 | 2023 | KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma. | 0 |
| 37751135 | 2023 | Biological Functions of the KDM2 Family of Histone Demethylases. | 1 |
| 35306360 | 2022 | Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors. | 1 |
| 35580699 | 2022 | KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer. | 2 |
| 35306360 | 2022 | Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors. | 1 |
| 35580699 | 2022 | KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer. | 2 |
| 33091189 | 2021 | Inhibition of microRNA let-7b expression by KDM2B promotes cancer progression by targeting EZH2 in ovarian cancer. | 8 |
Citation
Dessen P
KDM2B (lysine demethylase 2B)
Atlas Genet Cytogenet Oncol Haematol. 2013-03-01
Online version: http://atlasgeneticsoncology.org/gene/53197/kdm2b-(lysine-demethylase-2b)
