CACUL1 (CDK2 associated cullin domain 1)

2013-03-01  

Identity

HGNC
CACUL1
LOCATION
10q26.11
LOCUSID
143384
ALIAS
C10orf46,CAC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 143384
MIM: 618764
HGNC: 23727
Ensembl: ENSG00000151893

Variants:

dbSNP: 143384
ClinVar: 143384
TCGA: ENSG00000151893
COSMIC: CACUL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151893ENST00000369151Q86Y37
ENSG00000151893ENST00000493518Q86Y37

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
368989882023The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei.8
368989882023The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei.8
340809642021CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma.0
340809642021CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma.0
315040732019CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer.12
315040732019CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer.12
278896102017CACUL1/CAC1 attenuates p53 activity through PML post-translational modification.5
278896102017CACUL1/CAC1 attenuates p53 activity through PML post-translational modification.5
270854592016CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells.3
270854592016CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells.3
263141982015miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1).2
263141982015miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1).2
231786852013Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1.11
233119972013CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line.9
238066932013CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells.9

Citation

Dessen P

CACUL1 (CDK2 associated cullin domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53216/cacul1-(cdk2-associated-cullin-domain-1)