CACUL1 (CDK2 associated cullin domain 1)

2013-03-01  

Identity

HGNC
LOCATION
10q26.11
LOCUSID
ALIAS
C10orf46,CAC1
FUSION GENES

Other Information

Locus ID:

NCBI: 143384
MIM: 618764
HGNC: 23727
Ensembl: ENSG00000151893

Variants:

dbSNP: 143384
ClinVar: 143384
TCGA: ENSG00000151893
COSMIC: CACUL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151893ENST00000369151Q86Y37
ENSG00000151893ENST00000493518Q86Y37

Expression (GTEx)

0
5
10
15
20
25

References

Pubmed IDYearTitleCitations
229030202012The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer.15
231786852013Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1.9
198290632009Identification and characterization of CAC1 as a novel CDK2-associated cullin.8
233119972013CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line.6
238066932013CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells.6
229826812012CAC1 negatively regulates RARα activity through cooperation with HDAC.5
224153522012Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients.4
240048342013Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1.4
278896102017CACUL1/CAC1 attenuates p53 activity through PML post-translational modification.3
263141982015miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1).2

Citation

Dessen P

CACUL1 (CDK2 associated cullin domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53216/cacul1-(cdk2-associated-cullin-domain-1)