CNOT3 (CCR4-NOT transcription complex subunit 3)

2013-04-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
IDDSADF,LENG2,NOT3,NOT3H

Other Information

Locus ID:

NCBI: 4849
MIM: 604910
HGNC: 7879
Ensembl: ENSG00000088038

Variants:

dbSNP: 4849
ClinVar: 4849
TCGA: ENSG00000088038
COSMIC: CNOT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088038ENST00000221232O75175
ENSG00000088038ENST00000221232A0A024R4R3
ENSG00000088038ENST00000358389O75175
ENSG00000088038ENST00000358389A0A024R4R3
ENSG00000088038ENST00000440571H7C148
ENSG00000088038ENST00000447684H7C3F5
ENSG00000088038ENST00000457463H0Y5X7
ENSG00000088038ENST00000471126H7C5J4
ENSG00000088038ENST00000496327A0A2R8Y691
ENSG00000088038ENST00000613073A0A087X0F9
ENSG00000088038ENST00000617930B7Z6J7
ENSG00000088038ENST00000644245A0A2R8Y7Z8
ENSG00000088038ENST00000646002A0A2R8Y6N5
ENSG00000088038ENST00000647082A0A2R8Y4W0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232634912013Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.153
231446302012CNOT3 is a modifier of PRPF31 mutations in retinitis pigmentosa with incomplete penetrance.48
241212322013Structure and assembly of the NOT module of the human CCR4-NOT complex.40
223677592012Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.24
209701192011Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.18
241169172014Dominant PRPF31 mutations are hypostatic to a recessive CNOT3 polymorphism in retinitis pigmentosa: a novel phenomenon of "linked trans-acting epistasis".13
223429802012Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression.7
278993792017Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.5
286156932017The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.5
222946402012A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis.3

Citation

Dessen P

CNOT3 (CCR4-NOT transcription complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53235/cnot3-(ccr4-not-transcription-complex-subunit-3)