COPS8 (COP9 signalosome subunit 8)

2013-04-01  

Identity

HGNC
COPS8
LOCATION
2q37.3
LOCUSID
10920
ALIAS
COP9,CSN8,SGN8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10920
MIM: 616011
HGNC: 24335
Ensembl: ENSG00000198612

Variants:

dbSNP: 10920
ClinVar: 10920
TCGA: ENSG00000198612
COSMIC: COPS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198612ENST00000354371Q99627
ENSG00000198612ENST00000354371A0A024R4D1
ENSG00000198612ENST00000392008Q99627
ENSG00000198612ENST00000409334E9PGT6
ENSG00000198612ENST00000419015F8WEF2
ENSG00000198612ENST00000447464H7C3S9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127321432003The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.265
173181782007CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.81
203991882010Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.32
229923432012microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer.26
184244332008The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.8
236895092013COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.7
280631092017Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study.2
224140632012Purification of the COP9 signalosome complex and binding partners from human T cells.1

Citation

Dessen P

COPS8 (COP9 signalosome subunit 8)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53242/cops8-(cop9-signalosome-subunit-8)