NFE2L1 (nuclear factor, erythroid 2 like 1)

2013-04-01  

Identity

HGNC
NFE2L1
LOCATION
17q21.32
LOCUSID
4779
ALIAS
LCR-F1,NRF1,TCF11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4779
MIM: 163260
HGNC: 7781
Ensembl: ENSG00000082641

Variants:

dbSNP: 4779
ClinVar: 4779
TCGA: ENSG00000082641
COSMIC: NFE2L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082641ENST00000357480Q14494
ENSG00000082641ENST00000361665J9JIE5
ENSG00000082641ENST00000362042Q14494
ENSG00000082641ENST00000536222F5H1B7
ENSG00000082641ENST00000577411J3KSR3
ENSG00000082641ENST00000577431J3QQQ1
ENSG00000082641ENST00000579537J3KSE0
ENSG00000082641ENST00000579889A0A0G2JLG9
ENSG00000082641ENST00000580037J3QQH8
ENSG00000082641ENST00000580050J3QRG7
ENSG00000082641ENST00000581319J3KRF3
ENSG00000082641ENST00000582155B4DYE1
ENSG00000082641ENST00000583210J3QR31
ENSG00000082641ENST00000583378J3QKY3
ENSG00000082641ENST00000584137J3QLQ1
ENSG00000082641ENST00000584634J3KTG6
ENSG00000082641ENST00000585062J3QQY8
ENSG00000082641ENST00000585291Q14494

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379960592024Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.1
386564052024Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.0
379960592024Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.1
386564052024Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.0
374737012023Unravelling the role of NFE2L1 in stress responses and related diseases.3
376581352023The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.4
376818972023Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage.1
377399872023Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer.1
378487562023NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.1
380110902023Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells.0
374737012023Unravelling the role of NFE2L1 in stress responses and related diseases.3
376581352023The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.4
376818972023Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage.1
377399872023Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer.1
378487562023NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.1

Citation

Dessen P

NFE2L1 (nuclear factor, erythroid 2 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53247/nfe2l1-(nuclear-factor-erythroid-2-like-1)