PDE9A (phosphodiesterase 9A)

Identity

HGNC

PDE9A

LOCATION

21q22.3

LOCUSID

5152

ALIAS

HSPDE9A2

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 5152
MIM: 602973
HGNC: 8795
Ensembl: ENSG00000160191

Variants:

dbSNP: 5152
ClinVar: 5152
TCGA: ENSG00000160191
COSMIC: PDE9A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160191	ENST00000291539	O76083
ENSG00000160191	ENST00000291539	A0A0S2Z4T6
ENSG00000160191	ENST00000328862	O76083
ENSG00000160191	ENST00000335440	O76083
ENSG00000160191	ENST00000335512	O76083
ENSG00000160191	ENST00000335512	A0A0S2Z4A3
ENSG00000160191	ENST00000349112	O76083
ENSG00000160191	ENST00000349112	A0A0S2Z475
ENSG00000160191	ENST00000380328	O76083
ENSG00000160191	ENST00000398224	O76083

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Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
cGMP effects	REACTOME	R-HSA-418457
Hemostasis	REACTOME	R-HSA-109582
Nitric oxide stimulates guanylate cyclase	REACTOME	R-HSA-392154
Platelet homeostasis	REACTOME	R-HSA-418346
Purine metabolism	KEGG	ko00230
Purine metabolism	KEGG	hsa00230

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	119
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	119
21336703	2011	Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.	8
21736695	2012	Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study.	6
21736695	2012	Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study.	6
22328573	2012	Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.	30
22328573	2012	Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.	30
22960860	2012	Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors.	29
22960860	2012	Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors.	29
25799991	2015	Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.	157

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Citation

Dessen P

PDE9A (phosphodiesterase 9A)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53249/pde9a-(phosphodiesterase-9a)