ADCY10 (adenylate cyclase 10)

2013-04-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
HCA2,HEL-S-7a,SAC,SACI,Sacy,hsAC
FUSION GENES

Other Information

Locus ID:

NCBI: 55811
MIM: 605205
HGNC: 21285
Ensembl: ENSG00000143199

Variants:

dbSNP: 55811
ClinVar: 55811
TCGA: ENSG00000143199
COSMIC: ADCY10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143199ENST00000367848Q96PN6
ENSG00000143199ENST00000367851Q96PN6
ENSG00000143199ENST00000367851A0A0K0K1J8
ENSG00000143199ENST00000476818U3KPS9
ENSG00000143199ENST00000485964V9GY51
ENSG00000143199ENST00000545172Q96PN6

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
175919882007Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.51
241000332013CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.37
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
219949382011Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.27
201305942010Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.18
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
232556112013Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells.15
254099312015Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.14
182094742008Control of basal CFTR gene expression by bicarbonate-sensitive adenylyl cyclase in human pulmonary cells.12

Citation

Dessen P

ADCY10 (adenylate cyclase 10)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53251/adcy10-(adenylate-cyclase-10)