BCAN (brevican)

2013-05-01  

Identity

HGNC
LOCATION
1q23.1
LOCUSID
ALIAS
BEHAB,CSPG7
FUSION GENES

Other Information

Locus ID:

NCBI: 63827
MIM: 600347
HGNC: 23059
Ensembl: ENSG00000132692

Variants:

dbSNP: 63827
ClinVar: 63827
TCGA: ENSG00000132692
COSMIC: BCAN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132692ENST00000329117Q96GW7
ENSG00000132692ENST00000361588Q96GW7
ENSG00000132692ENST00000424639Q5T3I6
ENSG00000132692ENST00000441358Q5T3I8
ENSG00000132692ENST00000457777Q5T3I7
ENSG00000132692ENST00000479949V9GY88
ENSG00000132692ENST00000491823V9GXZ8

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective CHSY1 causes TPBSREACTOMER-HSA-3595177
Defective CHST3 causes SEDCJDREACTOMER-HSA-3595172
Defective CHST14 causes EDS, musculocontractural typeREACTOMER-HSA-3595174
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870
Dermatan sulfate biosynthesisREACTOMER-HSA-2022923
CS/DS degradationREACTOMER-HSA-2024101
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161335472005Human glioblastomas overexpress ADAMTS-5 that degrades brevican.36
186118542008The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.34
229307472012Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.29
160616542005Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas.21
219971792012Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma.18
209507962011Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.15
199105432010Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.6
118739412002Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.0

Citation

Dessen P

BCAN (brevican)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53253/bcan-(brevican)