HOXB3 (homeobox B3)

2013-05-01  

Identity

HGNC
HOXB3
LOCATION
17q21.32
LOCUSID
3213
ALIAS
HOX2,HOX2G,Hox-2.7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3213
MIM: 142966
HGNC: 5114
Ensembl: ENSG00000120093

Variants:

dbSNP: 3213
ClinVar: 3213
TCGA: ENSG00000120093
COSMIC: HOXB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120093ENST00000311626P14651
ENSG00000120093ENST00000460160P14651
ENSG00000120093ENST00000465120F8W1L2
ENSG00000120093ENST00000470495P14651
ENSG00000120093ENST00000471459C9J2I3
ENSG00000120093ENST00000472863P14651
ENSG00000120093ENST00000476342P14651
ENSG00000120093ENST00000489475P14651
ENSG00000120093ENST00000490677F8VXG0
ENSG00000120093ENST00000498678P14651

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198541322009Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.40
149662722004Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.31
156744122005A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.23
194779232009Induction of HoxB transcription by retinoic acid requires actin polymerization.23
232198992013HoxB3 promotes prostate cancer cell progression by transactivating CDCA3.18
280754532017miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer.17
274473022016miR-10b Inhibits Apoptosis and Promotes Proliferation and Invasion of Endometrial Cancer Cells via Targeting HOXB3.13
264828522015The role of HOXB2 and HOXB3 in acute myeloid leukemia.12
179721632009HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells.11
294396692018A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia.10

Citation

Dessen P

HOXB3 (homeobox B3)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53269/hoxb3-(homeobox-b3)