Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7284
MIM: 602389
HGNC: 12420
Ensembl: ENSG00000178952
Variants:
dbSNP: 7284
ClinVar: 7284
TCGA: ENSG00000178952
COSMIC: TUFM
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178952 | ENST00000313511 | P49411 |
| ENSG00000178952 | ENST00000313511 | A0A384ME17 |
| ENSG00000178952 | ENST00000565012 | H3BNU3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Organelle biogenesis and maintenance | REACTOME | R-HSA-1852241 |
| Mitochondrial translation | REACTOME | R-HSA-5368287 |
| Mitochondrial translation elongation | REACTOME | R-HSA-5389840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37461298 | 2023 | Novel Tu translation elongation factor, mitochondrial (TUFM) homozygous variant in a consanguineous family with premature ovarian insufficiency. | 4 |
| 37461298 | 2023 | Novel Tu translation elongation factor, mitochondrial (TUFM) homozygous variant in a consanguineous family with premature ovarian insufficiency. | 4 |
| 33774866 | 2021 | TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS. | 8 |
| 33774866 | 2021 | TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS. | 8 |
| 32061931 | 2020 | Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection. | 7 |
| 32061931 | 2020 | Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection. | 7 |
| 28132884 | 2017 | Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation. | 7 |
| 28449687 | 2017 | Expression and clinicopathologic significance of TUFM and p53 for the normal-adenoma-carcinoma sequence in colorectal epithelia. | 10 |
| 28611246 | 2017 | Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy. | 31 |
| 28132884 | 2017 | Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation. | 7 |
| 28449687 | 2017 | Expression and clinicopathologic significance of TUFM and p53 for the normal-adenoma-carcinoma sequence in colorectal epithelia. | 10 |
| 28611246 | 2017 | Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy. | 31 |
| 26781467 | 2016 | TUFM downregulation induces epithelial-mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3β signaling. | 27 |
| 26876213 | 2016 | EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex. | 39 |
| 26781467 | 2016 | TUFM downregulation induces epithelial-mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3β signaling. | 27 |
Citation
Dessen P
TUFM (Tu translation elongation factor, mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2013-05-01
Online version: http://atlasgeneticsoncology.org/gene/53287/tufm-(tu-translation-elongation-factor-mitochondrial)
