UNC119 (unc-119 lipid binding chaperone)

2013-05-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
HRG4,IMD13,POC7,POC7A
FUSION GENES

Other Information

Locus ID:

NCBI: 9094
MIM: 604011
HGNC: 12565
Ensembl: ENSG00000109103

Variants:

dbSNP: 9094
ClinVar: 9094
TCGA: ENSG00000109103
COSMIC: UNC119

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109103ENST00000301032Q13432
ENSG00000109103ENST00000335765Q13432
ENSG00000109103ENST00000444148C9JSK0
ENSG00000109103ENST00000470125K7EJU3
ENSG00000109103ENST00000484980K7EN86
ENSG00000109103ENST00000581945J3QQT8

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
325544672020The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.3
325544672020The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.3
316793072019Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression.5
316793072019Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression.5
295527812018UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β-catenin and TGF-β/EMT signaling pathways.3
295527822018UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β/catenin and TGF/β-EMT signaling pathways.0
299317882018UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53.4
306107992018UNC119 promoted cell growth and migration by Wnt/β-catenin signal and TGF-β/EMT signal pathway in hepatocellular carcinoma.1
295527812018UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β-catenin and TGF-β/EMT signaling pathways.3
295527822018UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β/catenin and TGF/β-EMT signaling pathways.0
299317882018UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53.4
306107992018UNC119 promoted cell growth and migration by Wnt/β-catenin signal and TGF-β/EMT signal pathway in hepatocellular carcinoma.1
287401332017Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.10
289351362017Coordinating the uncoordinated: UNC119 trafficking in cilia.5
287401332017Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.10

Citation

Dessen P

UNC119 (unc-119 lipid binding chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53291/unc119-(unc-119-lipid-binding-chaperone)