OGDHL (oxoglutarate dehydrogenase L)

2013-05-01  

Identity

HGNC
LOCATION
10q11.23
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 55753
MIM: 617513
HGNC: 25590
Ensembl: ENSG00000197444

Variants:

dbSNP: 55753
ClinVar: 55753
TCGA: ENSG00000197444
COSMIC: OGDHL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197444ENST00000374103Q9ULD0
ENSG00000197444ENST00000419399Q9ULD0
ENSG00000197444ENST00000432695Q9ULD0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Citrate cycle (TCA cycle)KEGGhsa00020
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360004932023Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.4
380311872023Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity.0
360004932023Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.4
380311872023Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity.0
334053942021OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer.10
348003632021Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia.12
334053942021OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer.10
348003632021Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia.12
309041692020Aberrant hypermethylation of OGDHL gene promoter in sporadic colorectal cancer.7
318370012020Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women.7
318992052020OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.66
309041692020Aberrant hypermethylation of OGDHL gene promoter in sporadic colorectal cancer.7
318370012020Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women.7
318992052020OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.66
311750942019A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis.14

Citation

Dessen P

OGDHL (oxoglutarate dehydrogenase L)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53296/ogdhl-(oxoglutarate-dehydrogenase-l)