GSTK1 (glutathione S-transferase kappa 1)

2013-05-01  

Identity

HGNC
GSTK1
LOCATION
7q34
LOCUSID
373156
ALIAS
GST,GST

Other Information

Locus ID:

NCBI: 373156
MIM: 602321
HGNC: 16906
Ensembl: ENSG00000197448

Variants:

dbSNP: 373156
ClinVar: 373156
TCGA: ENSG00000197448
COSMIC: GSTK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197448ENST00000358406Q9Y2Q3
ENSG00000197448ENST00000358406Q6FII1
ENSG00000197448ENST00000409500Q9Y2Q3
ENSG00000197448ENST00000436038C9JNT3
ENSG00000197448ENST00000442394E9PFN5
ENSG00000197448ENST00000443571Q9Y2Q3
ENSG00000197448ENST00000479303Q9Y2Q3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363284472022[Multifaceted Clinical Research on Obesity-related Disease Prevention Focusing on the DsbA-L Gene].0
363284472022[Multifaceted Clinical Research on Obesity-related Disease Prevention Focusing on the DsbA-L Gene].0
335383022021T cell metabolism in obesity and beyond: comments on 'DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production'.1
335383022021T cell metabolism in obesity and beyond: comments on 'DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production'.1
315027012020Plasma mtDNA copy numbers are associated with GSTK1 expression and inflammation in type 2 diabetes.5
321671392020DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.16
322498442020The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.5
329487512020DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.40
338431642020Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.6
315027012020Plasma mtDNA copy numbers are associated with GSTK1 expression and inflammation in type 2 diabetes.5
321671392020DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.16
322498442020The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.5
329487512020DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.40
338431642020Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.6
306069292019[A Multifaceted Approach regarding the Association of the DsbA-L Gene with the Risk of Obesity-related Diseases Based on Clinical Pharmacogenetics].0

Citation

Dessen P

GSTK1 (glutathione S-transferase kappa 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53300/gstk1-(glutathione-s-transferase-kappa-1)