WLS (Wnt ligand secretion mediator)

2013-05-01 Affiliation

Identity

HGNC

WLS

LOCATION

1p31.3

LOCUSID

79971

ALIAS

C1orf139,EVI,GPR177,MRP,mig-14

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79971
MIM: 611514
HGNC: 30238
Ensembl: ENSG00000116729

Variants:

dbSNP: 79971
ClinVar: 79971
TCGA: ENSG00000116729
COSMIC: WLS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116729	ENST00000262348	Q5T9L3
ENSG00000116729	ENST00000354777	Q5T9L3
ENSG00000116729	ENST00000370971	Q7Z430
ENSG00000116729	ENST00000370973	E9PKJ0
ENSG00000116729	ENST00000370976	Q5T9L3
ENSG00000116729	ENST00000471243	E9PQK1
ENSG00000116729	ENST00000491076	E9PM23
ENSG00000116729	ENST00000527864	H0YDL2
ENSG00000116729	ENST00000530486	E9PM62
ENSG00000116729	ENST00000533537	E9PJW4
ENSG00000116729	ENST00000534713	H0YCG9

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
WNT ligand biogenesis and trafficking	REACTOME	R-HSA-3238698

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36374649	2023	Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis.	7
36763105	2023	The role of Evi/Wntless in exporting Wnt proteins.	0
37005218	2023	Compound heterozygous variants in WLS gene causes Zaki syndrome.	0
37106064	2023	Expanding the phenotypic spectrum and clinical severity associated with WLS gene.	0
36374649	2023	Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis.	7
36763105	2023	The role of Evi/Wntless in exporting Wnt proteins.	0
37005218	2023	Compound heterozygous variants in WLS gene causes Zaki syndrome.	0
37106064	2023	Expanding the phenotypic spectrum and clinical severity associated with WLS gene.	0
35385340	2022	GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.	22
35385340	2022	GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.	22
33357447	2021	Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.	24
34015469	2021	Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses.	2
34315898	2021	Cryo-EM structure of human Wntless in complex with Wnt3a.	9
33357447	2021	Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.	24
34015469	2021	Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses.	2

Citation

Dessen P

WLS (Wnt ligand secretion mediator)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53306/wls-(wnt-ligand-secretion-mediator)