VAMP7 (vesicle associated membrane protein 7)

2013-05-01 Affiliation

Identity

HGNC

VAMP7

LOCATION

Xq28

LOCUSID

6845

ALIAS

SYBL1,TI-VAMP,TIVAMP,VAMP-7

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6845
MIM: 300053
HGNC: 11486
Ensembl: ENSG00000124333

Variants:

dbSNP: 6845
ClinVar: 6845
TCGA: ENSG00000124333
COSMIC: VAMP7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124333	ENST00000262640	P51809
ENSG00000124333	ENST00000262640	A0A024R074
ENSG00000124333	ENST00000286448	P51809
ENSG00000124333	ENST00000286448	A0A024R061
ENSG00000124333	ENST00000460621	P51809
ENSG00000124333	ENST00000488344	E5RH06

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
SNARE interactions in vesicular transport	KEGG	ko04130
SNARE interactions in vesicular transport	KEGG	hsa04130
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
trans-Golgi Network Vesicle Budding	REACTOME	R-HSA-199992
Clathrin derived vesicle budding	REACTOME	R-HSA-421837
Golgi Associated Vesicle Biogenesis	REACTOME	R-HSA-432722
Lysosome Vesicle Biogenesis	REACTOME	R-HSA-432720
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19781582	2009	TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways.	135
18571410	2008	MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.	81
18775314	2008	Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.	67
23322049	2013	hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.	48
22002060	2011	Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration.	45
19745841	2009	Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth.	37
18253931	2008	Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.	35
26553929	2015	Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.	32
18819912	2008	Role of HRB in clathrin-dependent endocytosis.	31
22589474	2012	Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.	31

Citation

Dessen P

VAMP7 (vesicle associated membrane protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53320/vamp7-(vesicle-associated-membrane-protein-7)