SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1)

2013-05-01  

Identity

HGNC
SCUBE1
LOCATION
22q13.2
LOCUSID
80274
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80274
MIM: 611746
HGNC: 13441
Ensembl: ENSG00000159307

Variants:

dbSNP: 80274
ClinVar: 80274
TCGA: ENSG00000159307
COSMIC: SCUBE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159307ENST00000290460B1AH90
ENSG00000159307ENST00000360835Q8IWY4
ENSG00000159307ENST00000449304H0Y4Y9
ENSG00000159307ENST00000615096A0A087X285

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382596702024SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7.0
382596702024SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7.0
365179782023Predictive Value of Combined Plasma D-Dimer, SCUBE1, and Right Ventricular Tei Index for the Prognosis of Elderly Patients with Acute Pulmonary Thromboembolism.1
367484012023The diagnostic potential of plasma SCUBE-1 concentration for pulmonary embolism: A pilot study.1
371980102023Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?0
365179782023Predictive Value of Combined Plasma D-Dimer, SCUBE1, and Right Ventricular Tei Index for the Prognosis of Elderly Patients with Acute Pulmonary Thromboembolism.1
367484012023The diagnostic potential of plasma SCUBE-1 concentration for pulmonary embolism: A pilot study.1
371980102023Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?0
363343962022SCUBE1 is associated with thrombotic complications, disease severity, and in-hospital mortality in COVID-19 patients.1
363343962022SCUBE1 is associated with thrombotic complications, disease severity, and in-hospital mortality in COVID-19 patients.1
342922902021Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery.1
342922902021Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery.1
316681022020Evaluation of SCUBE-1 levels as a placental dysfunction marker at gestational diabetes mellitus.5
317718602020De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.47
319915282020The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.1

Citation

Dessen P

SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53325/scube1-(signal-peptide-cub-domain-and-egf-like-domain-containing-1)