SRRT (serrate, RNA effector molecule)

2013-05-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ARS2,ASR2,serrate
FUSION GENES

Other Information

Locus ID:

NCBI: 51593
MIM: 614469
HGNC: 24101
Ensembl: ENSG00000087087

Variants:

dbSNP: 51593
ClinVar: 51593
TCGA: ENSG00000087087
COSMIC: SRRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087087ENST00000423692H7C0U8
ENSG00000087087ENST00000431645C9JUL9
ENSG00000087087ENST00000445337A0A0A0MSP6
ENSG00000087087ENST00000448764H7C3A1
ENSG00000087087ENST00000449389H7C1K0
ENSG00000087087ENST00000611405Q9BXP5
ENSG00000087087ENST00000614370A0A087X0F4
ENSG00000087087ENST00000614484Q9BXP5
ENSG00000087087ENST00000618262Q9BXP5
ENSG00000087087ENST00000618411Q9BXP5
ENSG00000087087ENST00000641476A0A286YEP7

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340606202021ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.6
340606202021ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.6
318188792020ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End Processing and Stability of NEAT1 Long Noncoding RNA.13
324634522020Mapping domains of ARS2 critical for its RNA decay capacity.8
325329772020ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.58
318188792020ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End Processing and Stability of NEAT1 Long Noncoding RNA.13
324634522020Mapping domains of ARS2 critical for its RNA decay capacity.8
325329772020ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.58
305188112019Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis.10
305188112019Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis.10
297039532018Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.34
297756462018The RNA binding protein Ars2 supports hematopoiesis at multiple levels.8
303490532018Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p.4
305426992018Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway.6
297039532018Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.34

Citation

Dessen P

SRRT (serrate, RNA effector molecule)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53328/srrt-(serrate-rna-effector-molecule)