MYO9B (myosin IXB)

2013-06-01  

Identity

HGNC
MYO9B
LOCATION
19p13.11
LOCUSID
4650
ALIAS
CELIAC4,MYR5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4650
MIM: 602129
HGNC: 7609
Ensembl: ENSG00000099331

Variants:

dbSNP: 4650
ClinVar: 4650
TCGA: ENSG00000099331
COSMIC: MYO9B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099331ENST00000397274Q13459
ENSG00000099331ENST00000594824M0R0P8
ENSG00000099331ENST00000594971M0QZY4
ENSG00000099331ENST00000595618Q13459
ENSG00000099331ENST00000595641M0R300
ENSG00000099331ENST00000596942M0R332
ENSG00000099331ENST00000597073M0QXP0
ENSG00000099331ENST00000598419M0R240
ENSG00000099331ENST00000602158M0QXX1
ENSG00000099331ENST00000602177M0R2J3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362603682023Mutations in MYO9B are associated with Charcot-Marie-Tooth disease type 2 neuropathies and isolated optic atrophy.1
377491402023Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.0
362603682023Mutations in MYO9B are associated with Charcot-Marie-Tooth disease type 2 neuropathies and isolated optic atrophy.1
377491402023Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.0
332683762021Local Myo9b RhoGAP activity regulates cell motility.7
332683762021Local Myo9b RhoGAP activity regulates cell motility.7
324518672020Class IX Myosins: Motorized RhoGAP Signaling Molecules.4
326929112020The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets.7
330465032020TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T(H)1/T(H)17 Cell Response.6
324518672020Class IX Myosins: Motorized RhoGAP Signaling Molecules.4
326929112020The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets.7
330465032020TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T(H)1/T(H)17 Cell Response.6
297020642018Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316.27
297020642018Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316.27
286270892017Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease.4

Citation

Dessen P

MYO9B (myosin IXB)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53330