TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2)

2013-06-01  

Identity

HGNC
TPTE2
LOCATION
13q12.11
LOCUSID
93492
ALIAS
TPIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 93492
MIM: 606791
HGNC: 17299
Ensembl: ENSG00000132958

Variants:

dbSNP: 93492
ClinVar: 93492
TCGA: ENSG00000132958
COSMIC: TPTE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132958ENST00000255310Q6XPS3
ENSG00000132958ENST00000382978Q6XPS3
ENSG00000132958ENST00000390680Q6XPS3
ENSG00000132958ENST00000400103Q6XPS3
ENSG00000132958ENST00000400230Q6XPS3
ENSG00000132958ENST00000462409G3V171

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
228966662012A human phospholipid phosphatase activated by a transmembrane control module.11
223110482012Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells.5
256767062015Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells.5
221642912011A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.4

Citation

Dessen P

TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53335/tpte2-(transmembrane-phosphoinositide-3-phosphatase-and-tensin-homolog-2)