TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2)

2013-06-01  

Identity

HGNC
TPTE2
LOCATION
13q12.11
LOCUSID
93492
ALIAS
TPIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 93492
MIM: 606791
HGNC: 17299
Ensembl: ENSG00000132958

Variants:

dbSNP: 93492
ClinVar: 93492
TCGA: ENSG00000132958
COSMIC: TPTE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132958ENST00000255310Q6XPS3
ENSG00000132958ENST00000382978Q6XPS3
ENSG00000132958ENST00000390680Q6XPS3
ENSG00000132958ENST00000400103Q6XPS3
ENSG00000132958ENST00000400230Q6XPS3
ENSG00000132958ENST00000462409G3V171

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514

References

Pubmed IDYearTitleCitations
256767062015Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells.6
256767062015Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells.6
223110482012Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells.6
228966662012A human phospholipid phosphatase activated by a transmembrane control module.16
223110482012Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells.6
228966662012A human phospholipid phosphatase activated by a transmembrane control module.16
221642912011A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.5
221642912011A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.5
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53335/tpte2-(transmembrane-phosphoinositide-3-phosphatase-and-tensin-homolog-2)